High-precision molecular assembly is governed by a delicate balance between repulsive and attractive supramolecular forces, excited by thermal fluctuations, which prevent the formation of kinetically trapped states and structural polymorphism ( 2– 4). It is remarkable that the self-assembly of complex structures in dense and crowded surroundings occurs with such a high degree of fidelity, as it requires a large number of molecular building blocks to come together in a precise order and orientation. Virtually all functional biological structures that form the basis of life, including protein complexes, lipid bilayers, and DNA double helix, self-assemble spontaneously from precisely defined building blocks guided by well-balanced supramolecular interactions ( 1). We show how allosteric activation of the associative interactions can suppress undesired solution-aggregation pathways and gives rise to a true template-assembly path.ĭespite its vast complexity, nature is able to construct functional nanostructures from small biomolecular building blocks with an astonishing precision and fidelity. We develop a minimal model to unravel the kinetic pathways and pathway selection of the templated assembly of molecular building blocks on a template. Designing effective template-guided self-assembling systems can only be realized through precise insight into how the chemical design of building blocks and the resulting balance of repulsive and attractive forces give rise to pathway selection and suppression of trapped states. Yet, nature’s templating strategy remains to be fully exploited in man-made nanomaterials. In nature, the use of molecular templates is a potent strategy to navigate the process to the desired structure with high fidelity. It relies on guiding building blocks through complex energy landscapes shaped by synergistic and antagonistic supramolecular interactions. This video on Vimeo provides some overview on how to export videos using custom settings from WLMM.Assembling large numbers of molecular building blocks into functional nanostructures is no trivial task. In terms of output, H.264 is not a file type, but a compression standard that can be applied to a number of different video "container formats" such as. If it were me I would want to ensure that the same processing was applied to every image in the sequence, so although some images may border on being under/over-exposed, transitions from light to dark and vice versa are captured properly. Looking at the online help for Windows Live Movie Maker, it seems that WLMM does notĪllow the import of RAW files, and so I guess you'll have to convert the images to something such as jpeg/tiff/png (See this answer for a guide to image file formats) first and then import these into WILMM to make your time-lapse. See this question for more discussion on this. I don't have access to Windows Live Movie Maker at the moment, but one reason why you may be having difficulties is because, strictly speaking, CR2 (or any type of RAW) files are not images they're just the data that is recorded by the camera when you press the shutter (so light levels plus details of the settings used and sometimes a little jpeg thumbnail image that shows what a typical image could look like when produced from this data).
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